NFL Week 1 Odds and Schedule – Latest Vegas Betting Odds for 2022 NFL Week 1 Action
The 2022 NFL regular season moves ahead with week 1 football action starting on Thursday, September 8th when the Buffalo Bills travel to SoFi Stadium to battle the defending Super Bowl Champion Los Angeles Rams.
The opening kick off is set for 8:20 pm est and the early opening odds are out at USA’s #1 online sportsbook, Bovada Sportsbook. The odds makers have posted the Bills as a -2.5 point favorite with the game total opening at over/under 52.5 points.
Week 1 NFL Odds
| Thursday, 8th September 2022 | SPREAD | TOTAL | ML | ||
|---|---|---|---|---|---|
| REGULAR SEASON – WEEK 1 | |||||
| 8:25 PM | |||||
| 451 | Bills | -2½ (-110) | 52½ (-110) | -135 |  |
| 452 | Rams | +2½ (-110) | 52½ (-110) | +115 | |
| Sunday, 11th September 2022 | SPREAD | TOTAL | ML | ||
| REGULAR SEASON – WEEK 1 | |||||
| 1:05 PM | |||||
| 453 | Ravens | -7 (-105) | 44½ (-110) | -305 | |
| 454 | Jets | +7 (-115) | 44½ (-110) | +245 | |
| 1:05 PM | |||||
| 455 | Saints | -5½ (-110) | 42½ (-110) | -235 | |
| 456 | Falcons | +5½ (-110) | 42½ (-110) | +190 | |
| 1:05 PM | |||||
| 457 | Patriots | +3 (-110) | 46½ (-110) | +135 | |
| 458 | Dolphins | -3 (-110) | 46½ (-110) | -160 | |
| 1:05 PM | |||||
| 459 | Browns | +2½ (-110) | 41½ (-110) | +115 | |
| 460 | Panthers | -2½ (-110) | 41½ (-110) | -135 | |
| 1:05 PM | |||||
| 461 | Steelers | +6½ (-110) | 44 (-110) | +225 | |
| 462 | Bengals | -6½ (-110) | 44 (-110) | -275 | |
| 1:05 PM | |||||
| 463 | 49ers | -7 (-110) | 41½ (-110) | -310 | |
| 464 | Bears | +7 (-110) | 41½ (-110) | +250 | |
| 1:05 PM | |||||
| 465 | Eagles | -4 (-110) | 48½ (-110) | -200 | |
| 466 | Lions | +4 (-110) | 48½ (-110) | +170 | |
| 1:05 PM | |||||
| 467 | Colts | -8 (-110) | 46 (-110) | -380 | |
| 468 | Texans | +8 (-110) | 46 (-110) | +300 | |
| 1:05 PM | |||||
| 469 | Jaguars | +3 (-110) | 44 (-110) | +140 | |
| 470 | Commanders | -3 (-110) | 44 (-110) | -165 | |
| 4:30 PM | |||||
| 471 | Chiefs | -4½ (-110) | 53½ (-110) | -210 | |
| 472 | Cardinals | +4½ (-110) | 53½ (-110) | +175 | |
| 4:30 PM | |||||
| 473 | Raiders | +3 (EV) | 52 (-110) | +155 | |
| 474 | Chargers | -3 (-120) | 52 (-110) | -185 | |
| 4:30 PM | |||||
| 475 | Packers | -1½ (-110) | 48 (-110) | -125 | |
| 476 | Vikings | +1½ (-110) | 48 (-110) | +105 | |
| 4:30 PM | |||||
| 477 | Giants | +5½ (-110) | 43½ (-110) | +205 | |
| 478 | Titans | -5½ (-110) | 43½ (-110) | -255 | |
| 8:25 PM | |||||
| 479 | Buccaneers | -1½ (-110) | 50 (-110) | -125 | |
| 480 | Cowboys | +1½ (-110) | 50 (-110) | +105 | |
| Monday, 12th September 2022 | SPREAD | TOTAL | ML | ||
| REGULAR SEASON – WEEK 1 | |||||
| 8:20 PM | |||||
| 481 | Broncos | -6 (-110) | 43 (-110) | -255 | |
| 482 | Seahawks | +6 (-110) | 43 (-110) | +205 | |
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